Ospanova Mariya
Karaganda Medical University, Kazakhstan
Title: Study of serotonin metabolism in children with congenital heart defects
Biography
Biography: Ospanova Mariya
Abstract
Abstract Background: The role of serotonin (5-HT) in the development of heart and vascular diseases, congenital heart defects (CHDs) complicated by pulmonary hypertension is being discussed in the world literature. The exact mechanisms responsible for the pathogenesis of the development of pulmonary arterial hypertension (PAH) have not yet been fully elucidated, endothelial dysfunction is associated with disorders of the 5-HT system.
The purpose of our study: was to study the metabolism of 5-HT against the background of surgical correction of CHDs in children.
Materials and methods: The study included 30 children with CHDs and different degrees of PAH. In addition to the generally accepted standard studies, indicators of the 5-HT system were determined: number of platelets, concentration of 5-HIAA in plasma, urine, platelets, 5-HT transporter (SERT), 5-HT2A receptors in platelets.
Results: of the study showed that despite the fact that 5-HT2A receptors on platelets do not undergo any special changes. SERT decreased by almost 20% after surgery (347.35±87.27 vs. 284.66±55.29 pg/10*9, p=0.03). Concentration of the 5-HIAA in and in platelets did not change significantly. However, concentration of 5-HIAA in urine before surgical treatment was 19.81±46.66 ng/mmol creatine, after - 6.51±10 ng/mmol creatine. Using the regression analysis, it was found that it is 5-HIAA in plasma that is determined by the level of the calculated average pressure in the pulmonary artery with a correlation coefficient of -0.59 (p<0.05).
Conclusion: The conducted studies and the results obtained the involvement of 5-HT metabolism in the pathophysiological mechanisms of the development of PAH associated with CHDs. Further study of the indicators of the 5-HT system will make it possible to identify early biomarkers for the development of PAH associated with CHDs.